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N-terminal domain antibody – NIH Director's Blog
May 18, 2021 · The researchers liken the spike protein to an umbrella, with the RBD at the tip of the “canopy.” While some antibodies do bind RBD at the tip, many others apparently target the protein’s canopy, known as the N-terminal domain (NTD). …
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Coronavirus N protein N-terminal domain (NTD) specifically ...
We show here that the N-terminal domain (NTD) of N protein from mouse hepatitis virus (MHV), a virus most closely related to SARS-CoV, employs aromatic amino acid-nucleobase stacking interactions with a triple adenosine motif to mediate high-affinity binding to single-stranded RNAs containing the transcriptional regulatory sequence (TRS) or its complement (cTRS).
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N-terminal domain antigenic mapping reveals a site of ...
Little is known about neutralizing Abs binding to epitopes outside the RBD and their contribution to protection. Here, we describe 41 human monoclonal Abs (mAbs) derived from memory B cells, which recognize the SARS-CoV-2 S N-terminal domain (NTD) and show that a subset of them neutralize SARS-CoV-2 ultrapotently.
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N-terminus - Wikipedia
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amine group is bonded to another carboxylicgroup in a protein to make it a chain, but since the end amino acid of a protein is only connected at the carboxy- end, the remaining free amine group i…
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The N-terminal domain plays a crucial role in the ...
Sep 16, 2016 · The N-terminal domain of both full-length S855A Lon structures was fitted in UCSF Chimera with six copies of a fragment of the E. coli Lon N-terminal domain crystal structure (PDB ID: …
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Novel structure of the N-terminal helical domain of BibA ...
One possible binding site for the BibA N-terminal domain was localized to the N-terminal CCP (complement-control protein) domains of the C4BP α-chain, as indicated by the decreased binding of BibA to a ΔCCP1 C4BP α-chain mutant. In summary, it is suggested that the GBS surface protein BibA, which consists of three antiparallel α-helical ...
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N Terminal Domain of S1 Protein: Potential Target for ...
Sep 17, 2020 · N Terminal Domain of S1 Protein: Potential Target for Coronavirus. The trimeric spike protein (S) present in SARS-CoV-2 plays a crucial part in the early stages of …
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An Allosteric Modulator of RNA Binding Targeting the N ...
In this study, we targeted the N-terminal domain (NTD) of transactive response (TAR) DNA binding protein (TDP-43), which is implicated in several neurodegenerative diseases. <i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to th …
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What is the N terminal domain of MHV?
We show here that the N-terminal domain (NTD) of N protein from mouse hepatitis virus (MHV), a virus most closely related to SARS-CoV, employs aromatic amino acid-nucleobase stacking interactions with a triple adenosine motif to mediate high-affinity binding to single-stranded RNAs containing the transcriptional regulatory sequence (TRS) ...
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What is the N terminal domain of S1?
Moreover, there is an additional part of the S1 protein known as the N terminal domain (NTD).
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What is the significance of the N-terminal amino acid?
The N-terminal amino acid of a protein is an important determinant of its half-life (likelihood of being degraded). This is called the N-end rule . The N-terminal signal peptide is recognized by the signal recognition particle (SRP) and results in the targeting of the protein to the secretory pathway.
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Where are the sites of N-terminal domain antigenic mapping?
6 Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium. 7 III Division of Infectious Diseases, Luigi Sacco Hospital, University of Milan, 20157 Milan, Italy. 8 Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
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