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Change in structure of the N‐terminal region of ...
N-terminus - Wikipedia
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The functional importance of the N-terminal region of ...
To understand the contribution of the N-terminal region to catalysis, an N-terminal truncated form, lacking 179 N-terminal residues of PRCP (rPRCP (40)) was constructed. The circular dichroism (CD) spectrum of rPRCP (40) illustrated that it was structured with significant helical content as indicated by local minima at approximately 220 and 208nm. The main products of Ang III metabolized by rPRCP …
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The N-Terminal Region of Severe Acute Respiratory Syndrome ...
Jan 27, 2010 · An intact N-terminal region was required for maximal inhibition of STAT1 translocation to the nucleus. While the C-terminal region of p6 is required for karyopherin α2 binding and inhibition of STAT1 translocation to the nucleus , the N-terminal region serves as a membrane anchor. To begin to define the structural requirements for this aspect of p6 function, we constructed a series of staggered …
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An Essential Role of the N-Terminal Region of ACSL1 in ...
We generated an ACSL1 mutant in which the N-terminal 100 amino acids were deleted and compared its localization and function with those of the ACSL1 wild type. We found that ACSL1 adjoined the outer membrane of mitochondria through interaction of its N-terminal region with carnitine palmitoyltransferase-1b (CPT1b) in C2C12 myotubes.
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The N-Terminal, Polybasic Region Is Critical for Prion ...
Sep 29, 2011 · Our results pinpoint the N-terminal, polybasic domain as a critical determinant of PrP C neuroprotective activity, and suggest that identification of molecules interacting with this region will provide important clues regarding the normal function of the protein. Small molecule ligands targeting this region may also represent useful therapeutic agents for treatment of prion diseases.
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N-Terminal Region of the Catalytic Domain of Human N ...
May 22, 2015 · Introduction. N -myristoyltransferase (NMT; EC 126.96.36.199) is a central switch in cellular signaling pathways, which catalyzes the covalent transfer of tetradecanoate (C14:0) to the N-terminal glycine in either a co- or post transnational manner [ 1 – 5 ].
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N-terminus - Wikipedia
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amine group is bonded to another carboxylicgroup in a protein to make it a chain, but since the end amino acid of a protein is only connected at the carboxy- end, the remaining free amine group i…
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EIF4E1B Antibody - N-terminal region (ARP66792_P050 ...
EIF4E1B Antibody - N-terminal region (ARP66792_P050), Catalog ARP66792_P050. Tested in WB applications. Reacts with Human samples. Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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A Novel N-terminal Region to Chromodomain in CHD7 is ...
Sep 03, 2021 · An N-terminal to Chromodomain (N-CRD) of CHD7 is identified as a novel nucleosome binding module. • N-CRD contains a high-conserved arginine stretch, a reminiscent of arginine anchor for interacting the acidic patch. • The acidic patch is required for CHD7 to bind and remodel nucleosomes. •
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What is the significance of the N-terminal amino acid?
The N-terminal amino acid of a protein is an important determinant of its half-life (likelihood of being degraded). This is called the N-end rule . The N-terminal signal peptide is recognized by the signal recognition particle (SRP) and results in the targeting of the protein to the secretory pathway.
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Where is the N-terminal peptide located in the cell?
The N-terminal signal peptide is recognized by the signal recognition particle (SRP) and results in the targeting of the protein to the secretory pathway. In eukaryotic cells, these proteins are synthesized at the rough endoplasmic reticulum.
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Where does N terminal acetylation occur in the cell?
N-terminal acetylation is a form of protein modification that can occur in both prokaryotes and eukaryotes. It has been suggested that N-terminal acetylation can prevent a protein from following a secretory pathway.
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What are the modifications of the N-terminus of a protein?
N-terminal modifications. Protein N-termini can be modified co - or posttranslationally. Modifications include the removal of initiator methionine (iMet) by aminopeptidases, attachment of small chemical groups such as acetyl, propionyl and methyl, and the addition of membrane anchors, such as palmitoyl and myristoyl groups.
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