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Synonymous vs. Nonsynonymous Mutations - Definitions
https://www.thoughtco.com/synonymous-vs-nonsynonymous-mutations-1224600
WEBJul 1, 2019 · Synonymous mutations do not change anything and no changes are made. That means they have no real role in the evolution of species since the gene or protein is not changed in any way. Synonymous mutations are actually fairly common, but since they have no effect, then they are not noticed.
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Understanding the contribution of synonymous mutations to
https://www.nature.com/articles/nrg3051
WEBAug 31, 2011 · Synonymous mutations — sometimes called 'silent' mutations — are now widely acknowledged to be able to cause changes in protein expression, conformation and function.
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Synonymous substitution - Wikipedia
https://en.wikipedia.org/wiki/Synonymous_substitution
WEBA synonymous substitution (often called a silent substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence is not modified.
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Synonymous mutations in representative yeast genes are mostly …
https://www.nature.com/articles/s41586-022-04823-w
WEBJun 8, 2022 · Nature - A survey of 8,341 mutations in 21 yeast genes shows that synonymous mutations are nearly as harmful as nonsynonymous mutations, in part because they both affect the mRNA level of...
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Molecular Mechanisms and the Significance of Synonymous Mutations …
https://www.mdpi.com/2218-273X/14/1/132
WEBJan 20, 2024 · If it results in a synonymous codon, often by changing only the third nucleotide or, in some cases, only the first nucleotide, it is called a synonymous mutation (SM). The term SM is relative and depends on what gene is used as a reference.
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Effects of Synonymous Mutations beyond Codon Bias: The …
https://academic.oup.com/gbe/article/13/9/evab141/6300525
WEBJun 16, 2021 · Introduction. Synonymous mutations do not alter the encoded amino acids but can still impact fitness via their effects on gene expression and protein structure. Evidence for these fitness effects now comes from a range of observational, comparative genomics, and experimental studies.
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Synonymous mutations reveal genome-wide levels of positive ... - Nature
https://www.nature.com/articles/s41588-021-00957-1
WEBNov 4, 2021 · Synonymous passenger mutations are used to measure levels of positive selection in healthy blood and esophagus. This approach can quantify missing selection due to unidentified drivers.
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Phenotypic Effects of Synonymous Mutations - Oxford Academic
https://academic.oup.com/gbe/pages/phenotypic-effects-synonymous-mutations
WEBSynonymous mutations are often assumed to be neutral with respect to fitness because they do not alter the encoded amino acid and so cannot be “seen” by natural selection. Yet a growing body of evidence suggests that synonymous mutations can have fitness effects that drive adaptive evolution ...
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Synonymous mutations that regulate translation speed might play …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033552/
WEBApr 9, 2021 · We found that synonymous mutations that increase the codon optimality could significantly enhance the translational velocity, and are enriched in oncogenes. The synonymous mutations that decrease codon optimality slow down translation, and are enriched in tumor suppressor genes.
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Exposing synonymous mutations - PubMed
https://pubmed.ncbi.nlm.nih.gov/24954581/
WEBA large repertoire of both experimental and bioinformatic methods has been developed to understand the effects of synonymous variants. Results from this body of work have provided global insights into how biological systems exploit the degeneracy of the genetic code to control gene expression, protein folding efficiency, and the coordinated ...
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