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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike
Apr 16, 2020 · The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SAR …
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Senolytic CAR T cells reverse senescence-associated pathologies
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment 1,2.Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant cells 3,4 and has a beneficial role in wound-healing responses 5,6.Pathologically, the aberrant accumulation of …
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