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FDA Drug Safety Communication: Update to ongoing safety review of Actos
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-update-ongoing-safety-review-actos-pioglitazone-and-increased-risk
WEBData Summary. References. Safety Announcement. [6-15-2011] The U.S. Food and Drug Administration (FDA) is informing the public that use of the diabetes medication Actos (pioglitazone) for more...
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Pioglitazone and bladder cancer risk: a systematic review and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911601/
WEBFeb 24, 2018 · Current evidence about the association between pioglitazone and bladder cancer risk remains conflict. We aimed to assess the risk of bladder cancer associated with the use of pioglitazone and identify modifiers that affect the results.
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FDA Drug Safety Communication: Updated FDA review …
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-updated-fda-review-concludes-use-type-2-diabetes-medicine-pioglitazone
WEB[ 12-12-2016 ] As a result of an updated review, the U.S. Food and Drug Administration (FDA) has concluded that use of the type 2 diabetes medicine pioglitazone (Actos, Actoplus Met, Actoplus...
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Pioglitazone use and risk of bladder cancer: a systematic …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357234/
WEBJun 14, 2018 · For bladder cancer outcome, the estimated effect size for ever vs. never use of pioglitazone was 1.16 [95% confidence interval (CI), 1.04–1.28]. In the cumulative dose and duration analyses, highest effect was observed in the highest/longest exposure group, but substantial heterogeneity was present.
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Pioglitazone and the Risk of Bladder Cancer: A Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544610/
WEBJun 16, 2017 · Additional risk factors for bladder cancer include increased age, male sex, smoking, occupational and environmental exposures, and urinary tract disease [ 10, 11 ]. Evidence linking the use of pioglitazone to the increased risk of bladder cancer is mixed.
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Pioglitazone - U.S. Food and Drug Administration
https://www.fda.gov/drugs/fda-drug-safety-podcasts/fda-drug-safety-podcast-updated-fda-review-concludes-use-pioglitazone-may-be-linked-increased-risk
WEBOn December 12, 2016, FDA announced as a result of an updated review, that it has concluded that use of the type 2 diabetes medicine pioglitazone (brand names Actos, Actoplus Met, Actoplus Met...
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Pioglitazone use and risk of bladder cancer: population based …
https://www.bmj.com/content/352/bmj.i1541
WEBMar 30, 2016 · Compared with no thiazolidinedione use, the use of pioglitazone was associated with an increased risk of incident bladder cancer (121.0 v 88.9 per 100 000 person years; adjusted hazard ratio 1.63, 95% confidence interval 1.22 to 2.19).
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Assessing the need for pioglitazone in the treatment of ... - Nature
https://www.nature.com/articles/s41598-020-72967-8
WEBSep 25, 2020 · Pio has no significant effect on bladder cancer nor macular oedema. Pio has salutary effects on MACE. The positive effects are completely offset by the harm they seem to cause by way of heart...
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Pioglitazone and bladder cancer risk: a systematic review and …
https://pubmed.ncbi.nlm.nih.gov/29476615/
WEBPMCID: PMC5911601. DOI: 10.1002/cam4.1354. Abstract. Current evidence about the association between pioglitazone and bladder cancer risk remains conflict. We aimed to assess the risk of bladder cancer associated with the use of pioglitazone and identify modifiers that affect the results.
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Pioglitazone Use and Risk of Bladder Cancer and Other Common …
https://jamanetwork.com/journals/jama/fullarticle/2397834
WEBJul 21, 2015 · Actos (pioglitazone HCl) [package insert]. Deerfield, IL: Takeda Pharmaceuticals America; 2013. Oleksiewicz MB, Southgate J, Iversen L, Egerod FL. Rat urinary bladder carcinogenesis by dual-acting PPARalpha + gamma agonists.
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