Keyword Analysis & Research: 5 alpha reductase production
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5α-Reductase - Wikipedia
https://en.wikipedia.org/wiki/5%CE%B1-Reductase
WebProduction and activity. The enzyme is produced in many tissues in both males and females, in the reproductive tract, testes and ovaries, skin, seminal vesicles, prostate, epididymis and many organs, including the nervous system. There are three isoenzymes of 5α-reductase: steroid 5α-reductase 1, 2, and 3 (SRD5A1, SRD5A2 and SRD5A3).
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5α-Reductases In Human Physiology: an Unfolding Story
https://www.endocrinepractice.org/article/S1530-891X(20)43023-X/fulltext
Web5a reductases convert testosterone, proges terone, deoxycorticosterone, aldosterone and corticoste rone into their respective 5a-dihydro-derivatives, which serve as substrates for 3a-hydroxysteroid dehydrogenase enzymes.
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The 5 Alpha-Reductase Isozyme Family: A Review of Basic …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253436/
WebDec 25, 2011 · Three isozymes of 5α-R are known to exist (5α-R1-3) and two other proteins exhibit 5-alpha reducing capabilities, glycoprotein synaptic 2 (GPSN2), and glycoprotein synaptic 2-like (GPSN2L) proteins. Only one 5 beta-reductase (5β …
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5-Alpha Reductase Deficiency: How It Affects Hormones
https://www.verywellhealth.com/5-alpha-reductase-deficiency-overview-and-more-5093532
WebApr 27, 2023 · Causes. 5-alpha-reductase deficiency is a rare hereditary disorder caused by the mutation of the SRD5A2 gene. It is an autosomal recessive mutation, meaning that you can only get it if both of your parents pass an SRD5A2 gene mutation to you. There are more than 60 different mutations that can cause this.
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5α-Reductase: History and Clinical Importance - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472916/
WebThe conversion of testosterone to dihydrotestosterone is catalyzed by the enzyme 5α-reductase (5AR), which exists in 2 forms: Type 1 and Type 2, both of which are found in the prostate. Type 1 is produced primarily in liver and skin and is carried to the prostate via the systemic circulation.
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Biochemistry, Dihydrotestosterone - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK557634/
WebJul 30, 2023 · 5-Alpha-Reductase Inhibitors 5-alpha-reductase inhibitors help treat conditions with excessive DHT activity. These conditions include benign prostatic hyperplasia (BPH), prostate cancer, androgenic alopecia (male …
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5α-Reductases In Human Physiology: an Unfolding Story
https://www.endocrinepractice.org/article/S1530-891X(20)43023-X/abstract
Web5a reductases convert testosterone, proges terone, deoxycorticosterone, aldosterone and corticoste rone into their respective 5a-dihydro-derivatives, which serve as substrates for 3a-hydroxysteroid dehydrogenase enzymes.
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5-Alpha Reductase - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/5-alpha-reductase
Web5-Alpha reductase is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), a potent androgen involved in male sexual differentiation. In the absence of DHT, undermasculinized external genitalia are observed; in severe enzyme deficiency, patients may be phenotypically female [176].
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5α-reductases in human physiology: an unfolding story
https://pubmed.ncbi.nlm.nih.gov/23246684/
WebResults: 5α reductases convert testosterone, progesterone, deoxycorticosterone, aldosterone and corticosterone into their respective 5α-dihydro-derivatives, which serve as substrates for 3α-hydroxysteroid dehydrogenase enzymes.
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The role of 5-reduction in physiology and metabolic disease ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/33418075/
WebThe 5-reductases (5α-reductase types 1, 2 and 3 [5αR1-3], 5β-reductase [5βR]) are steroid hormone metabolising enzymes that hold fundamental roles in human physiology and pathology.
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