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Wnt signaling pathway - Wikipedia
https://en.wikipedia.org/wiki/Wnt_signaling_pathway
WebThe Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. [1] Wnt signaling pathways use either nearby cell-cell communication ( paracrine) or same-cell communication ...
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Wnt/β-catenin signalling: function, biological mechanisms, and
https://www.nature.com/articles/s41392-021-00762-6
WebJan 3, 2022 · The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling...
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The origin and evolution of Wnt signalling - Nature
https://www.nature.com/articles/s41576-024-00699-w
WebFeb 19, 2024 · Wnt signalling is a crucial developmental pathway involved in various processes such as cell differentiation and the formation and polarity of the primary body axis 1. It is involved in all life...
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The complex world of WNT receptor signalling - Nature
https://www.nature.com/articles/nrm3470
WebNov 15, 2012 · WNT receptors and co-receptors are regulated intracellularly by phosphorylation, proteolytic processing and endocytosis. Endocytosis is a key mechanism, and WNT signalling requires endocytosis,...
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Mechanisms of Wnt signaling and control - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165711/
WebWnt signaling activity is modulated by three main mechanisms: (a) enzymatic inactivation by NOTUM, which cleaves off the essential lipid moiety, or by TIKI, which removes a portion of the amino terminus, (b) sequestration of Wnt by proteins such as WIF, SFRP, and Cer, and (C) receptor modulation by DKK, which binds LRP and Kremen to prevent the ...
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Everything You Would Like to Know About Wnt Signaling
https://www.science.org/doi/10.1126/scisignal.2004167
WebMay 14, 2013 · Wnts are secreted glycoproteins that bind to specific cell surface receptors and activate signaling in a mostly paracrine fashion. Wnts trigger distinct intracellular pathways, including canonical signaling through β-catenin and noncanonical planar cell polarity (PCP) and Ca 2+ signaling ( Fig. 1 ).
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An Updated Overview on Wnt Signaling Pathways
https://www.ahajournals.org/doi/full/10.1161/circresaha.110.219840
WebIn particular, Wnts have important functions in stem cell biology, cardiac development and differentiation, angiogenesis, cardiac hypertrophy, cardiac failure, and aging.
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The Emerging Mechanisms of Wnt Secretion and Signaling in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415634/
WebAug 16, 2021 · Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling pathways. These pathways regulate crucial processes during various stages of development and maintain tissue homeostasis in adults.
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Frontiers | The Emerging Mechanisms of Wnt Secretion and …
https://www.frontiersin.org/articles/10.3389/fcell.2021.714746/full
WebAug 16, 2021 · Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling pathways. These pathways regulate crucial processes during various stages of development and maintain tissue homeostasis in adults.
DA: 91 PA: 53 MOZ Rank: 68
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Wnt Pathway: An Integral Hub for Developmental and Oncogenic …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663720/
WebOct 28, 2020 · In this review, we provide an overview of the key components of the Wnt signaling pathway and the milestones in both developmental and cancer biology. We also describe some recently discovered components and functions and emerging links of Wnt signaling with cancer stemness and antitumor immunity.
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