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Tumor necrosis factor - Wikipedia
https://en.wikipedia.org/wiki/Tumor_necrosis_factor
WEBTumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. TNF signaling occurs through two receptors: TNFR1 and TNFR2.
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962638/
WEBMar 8, 2021 · Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to be involved in the pathogenesis of some inflammatory and autoimmune diseases [ 1 ].
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Tumor Necrosis Factor Alpha - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/tumor-necrosis-factor-alpha
WEBTumour necrosis factor α (TNFα) is a potent paracrine and endocrine mediator of inflammatory and immune functions. It is also known to regulate growth and differentiation of a wide variety of cells types. TNFα is selectively cytotoxic for many transformed cells, especially in combination with IFNα.
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Death by TNF: a road to inflammation | Nature Reviews Immunology
https://www.nature.com/articles/s41577-022-00792-3
WEBNov 15, 2022 · Karki, R. et al. Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell 184 , 149–168...
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The Role of Tumor Necrosis Factor Alpha (TNF-α) in …
https://pubmed.ncbi.nlm.nih.gov/33800290/
WEBMar 8, 2021 · PMCID: PMC7962638. DOI: 10.3390/ijms22052719. Abstract. Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases.
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Metabolic Messengers: tumour necrosis factor | Nature Metabolism
https://www.nature.com/articles/s42255-021-00470-z
WEBOct 14, 2021 · Tumour necrosis factor alpha (TNF-α), also known as TNF superfamily member 2 (TNFSF2) or simply TNF, is a multifunctional cytokine that has well-established immunological roles in innate...
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Tumour necrosis factor signalling in health and disease - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352924/
WEBJan 28, 2019 · Another glycolytic enzyme, alpha-enolase (ENO1), has been shown to have inflammatory effects when expressed on the surface of monocytes and macrophages by contributing to the production of inflammatory cytokines, such as TNF, in the synovium of patients with RA and also in the type II collagen model of arthritis 109.
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Tumor Necrosis Factor Inhibitors - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK482425/
WEBJul 3, 2023 · Continuing Education Activity. Tumor necrosis factor (TNF)-alpha inhibitors, including etanercept (E), infliximab (I), adalimumab (A), certolizumab pegol (C), and golimumab (G), are biologic agents which are FDA-approved to treat ankylosing spondylitis (E, I, A, C, and G), Crohn disease (I, A and C), hidradenitis suppurativa (A), juvenile ...
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Insights into the biology and therapeutic implications of TNF and
https://www.nature.com/articles/s41584-021-00639-6
WEBJul 5, 2021 · Tumour necrosis factor (TNF) is a major inflammatory cytokine that has deleterious effects in several rheumatic and autoimmune diseases as attested by the success of TNF inhibitor...
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TNF alpha and the TNF receptor superfamily: structure-function ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/10891884/
WEBAug 1, 2000 · TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.
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