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TGF alpha - Wikipedia
https://en.wikipedia.org/wiki/TGF_alpha
WebTransforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide. The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling.
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Transforming growth factor - Wikipedia
https://en.wikipedia.org/wiki/Transforming_growth_factor
WebTransforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms .
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From wavy hair to naked proteins: The role of transforming growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105142/
WebApr 4, 2015 · Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and …
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TGF Alpha - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/tgf-alpha
WebTransforming Growth Factor-α Gene and Protein. TGF-α was discovered as a secreted, EGF-like transforming activity in virally transformed cells. The human TGF-a gene is located on chromosome 2p11-13, contains 6 exons, and spans 70 to 100 kb of DNA (247, 248). Its 4.5- to 4.8-kb TGF-a mRNA transcript encodes a 160-amino-acid integral ...
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Transforming Growth Factor Alpha - an overview - ScienceDirect
https://www.sciencedirect.com/topics/neuroscience/transforming-growth-factor-alpha
WebTransforming Growth Factor Alpha. Transforming growth factor α (TGFα) is a 50 amino-acid polypeptide member of the epidermal growth factor (EGF) family with which it shares the same receptor, the EGF receptor (EGFR or erbB1). From: Progress in Neurobiology, 2000. Related terms: Tumor Necrosis Factor Alpha; Eicosanoid Receptor
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Transforming Growth Factor α and β (TGF-α and TGF-β)
https://link.springer.com/chapter/10.1007/978-3-319-28140-7_53
WebMar 11, 2016 · TGF-β signaling pathway is involved in many cellular processes in the developing embryo. TGF-α is involved in various corneal diseases and is responsible for the angiogenesis and epidermal hyperplasia in psoriasis and has influence in protection and healing of gastro-intestinal lesions.
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Transforming Growth Factor Alpha - an overview - ScienceDirect
https://www.sciencedirect.com/topics/immunology-and-microbiology/transforming-growth-factor-alpha
WebTransforming growth factor α (TGFα) is a member of the epidermal growth factor (EGF) family of cytokines. TGFα encodes a 17-kDa protein and is located on chromosome 2p13. It was originally observed in culture media of certain retrovirus transformed fibroblasts.
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Roles for transforming growth factor-alpha in gastric physiology …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2589761/
WebTGF alpha and EGFR, but not EGF, are expressed in normal gastric mucosa. We have identified the following biological roles for TGF alpha in the stomach, using a variety of primate and rodent models: inhibition of acid secretion; stimulation of mucous cell growth; protection against ethanol- and aspirin-induced injury.
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Transforming growth factor-alpha - PubMed
https://pubmed.ncbi.nlm.nih.gov/2271184/
WebIn summary, although TGF-alpha was initially found in tumors, a number of later studies, some of them from the author's laboratory, have shown that TGF-alpha should no longer be considered a tumor associated growth factor. Rather, TGF-alpha is a normal physiological ligand for the EGF receptor.
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Transforming growth factor alpha: expression, regulation and
https://pubmed.ncbi.nlm.nih.gov/2103501/
WebTransforming growth factor alpha (TGF alpha) is a 6 kDa polypeptide mitogen that interacts with the epidermal growth factor receptor and activates its intrinsic tyrosine kinase. The mature 50 amino acid TGF alpha is released from a 159 or 160 amino acid integral membrane glycoprotein precursor, deno ….
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