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Melas Syndrome - StatPearls - NCBI Bookshelf Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial disease primarily affecting the nervous system and muscles. MELAS presents in children or young adults as recurrent episodes of encephalopathy, myopathy, headache, and focal neurological deficits.What is Melas dementia?
This is an uncommon and rare type of dementia. MELAS is an acronym that stands for: ME– Mitochondrial Encephalopathy LA– Lactic Acidosis S– “Stroke-like” episodes. This usually is a syndrome that arises in childhood; commonly between the ages of two (2) and fifteen (15) years of age and mainly affects muscles and the nervous system. SymptomsWhat are the signs and symptoms of Melas in children?
Onset in older children typically presents as recurrent attacks of a migraine-like headache, anorexia, vomiting, and seizures. Children with MELAS are also frequently found to have short stature. Myopathy in MELAS initially presents as exercise intolerance or proximal muscle weakness.What causes recurrence of stroke-like episodes in MELAS syndrome?
The distinguishing feature in MELAS syndrome is the recurrence of stroke-like episodes. It is currently thought that the deficiency of a compound called nitric oxide in the small blood vessels of the brain may be responsible for the stroke-like episodes.