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About Mutations in the RET Gene - Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/cancer-care/patient-education/about-mutations-ret-gene
WEBJul 21, 2023 · Your RET gene normally helps prevent cancers. A mutation in this gene causes it to stop working like it should. It is important to understand that having a mutation in this gene does not mean you will definitely develop cancer. It means that you have an increased risk of developing certain types of cancers.
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RET gene: MedlinePlus Genetics
https://medlineplus.gov/genetics/gene/ret/
WEBThe RET gene provides instructions for producing a protein that is involved in signaling within cells. Learn about this gene and related health conditions.
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RET inhibitors: A treatment for any RET-altered cancer
https://www.mdanderson.org/cancerwise/ret-inhibitors--a-treatment-for-any-ret-altered-cancer.h00-159544479.html
WEBNovember 07, 2022. RET inhibitors: A treatment for any RET-altered cancer. BY Devon Carter. Cancer research is advancing rapidly, and patients are benefitting from new therapies faster than ever. One example is a type of targeted therapy known as …
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RET receptor signaling: Function in development, metabolic …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948417/
WEBMar 3, 2022 · The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are responsible for various human cancers and developmental disorders, including thyroid cancer, non-small cell lung cancer, multiple endocrine neoplasia type 2, and Hirschsprung’s disease. RET receptors are …
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New Drug Gives Young Thyroid Cancer Patient a Second Chance at Life
https://www.verywellhealth.com/ret-inhibitor-drug-thyroid-cancer-5093500
WEBJan 9, 2021 · The FDA approved pralsetinib ( Gavreto ), a selective RET-inhibitor drug, for RET fusion-positive non-small cell lung cancers (NSCLC) on September 4, 2020, and RET-altered thyroid cancers on December 1, 2020. This medication, and others like it, provide a more targeted treatment option for patients with these diagnoses.
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The importance of the RET gene in thyroid cancer and …
https://www.nature.com/articles/s41574-021-00470-9
WEBFeb 18, 2021 · Introduction. Since the discovery of the RET gene in 1985, considerable progress has been made in the understanding of its physiology and role in diseases, particularly thyroid cancer. RET...
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RET Gene - GeneCards | RET Protein | RET Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=RET
WEBApr 3, 2024 · RET (Ret Proto-Oncogene) is a Protein Coding gene. Diseases associated with RET include Hirschsprung Disease 1 and Multiple Endocrine Neoplasia, Type Iia. Among its related pathways are Gene expression …
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First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET
https://www.nejm.org/doi/full/10.1056/NEJMoa2309457
WEBOct 21, 2023 · Quick Take. First-Line Selpercatinib in RET Fusion–Positive NSCLC. 1m 52s. RET gene fusions, which lead to increased oncogenic signaling, are a targetable alteration in patients with RET...
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RET signaling pathway and RET inhibitors in human cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359433/
WEBJul 25, 2022 · Rearranged during transfection (RET) is one such receptor tyrosine kinase first discovered in 1985 as a novel transforming gene in NIH3T3 cells upon transfection with DNA isolated from human lymphoma cells ( 1 ), resulting in their oncogenic transformation.
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RET Inhibitors in Non-Small-Cell Lung Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431193/
WEBSep 1, 2021 · Introduction. The RET (Rearranged during Transfection) gene encodes a single-pass transmembrane receptor tyrosine kinase (RTK) physiologically involved in renal morphogenesis, neural and neuroendocrine tissue development as well as spermatogonial stem cell maintenance.
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