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Replication Fork Stalling and the Fork Protection Complex
https://www.nature.com/scitable/topicpage/replication-fork-stalling-and-the-fork-protection-14435782/
Figure 1: Replication fork components. The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork. The ...
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Replication fork stalling at natural impediments - PubMed
https://pubmed.ncbi.nlm.nih.gov/17347517/
Replication fork stalling at natural impediments Abstract Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. Author: Ekaterina V. Mirkin, Sergei M. Mirkin Publish Year: 2007
Author: Ekaterina V. Mirkin, Sergei M. Mirkin
Publish Year: 2007
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Replication Fork Stalling at Natural Impediments - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847372/
Another possibility is that stalling of the replication fork at promoters and terminators could promote recombination outside of the coding areas. It was shown that mitotic recombination events induced by DNA damage often occur in intergenic regions containing promoters and/or terminators of transcription . Note that this is different from meiotic recombination. Author: Ekaterina V. Mirkin, Sergei M. Mirkin Publish Year: 2007
Author: Ekaterina V. Mirkin, Sergei M. Mirkin
Publish Year: 2007
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Stalled DNA Replication Fork | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/recovering-a-stalled-replication-fork-14436634/
The stalling signal is deactivated when cells enter conditions allowing fork restart after DNA damage has been resolved. In addition, recombination and repair proteins are …
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Mechanisms for stalled replication fork stabilization: new …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123652/
Aug 13, 2018 · Replication forks frequently encounter obstacles that may cause genotoxic fork stalling. Nevertheless, failure to complete replication rarely occurs under normal conditions, which is attributed to an intricate network of proteins … Author: Hongwei Liao, Fang Ji, Thomas Helleday, Thomas Helleday, Songmin Ying Publish Year: 2018
Author: Hongwei Liao, Fang Ji, Thomas Helleday, Thomas Helleday, Songmin Ying
Publish Year: 2018
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Replication fork stalling elicits chromatin compaction for …
https://pubmed.ncbi.nlm.nih.gov/31262821/
When replication forks stall, H2BK33, a newly identified acetylation site, is deacetylated and H3K9 trimethylated in the nucleosomes surrounding stalling forks, which results in chromatin compaction around forks. Acetylation-mimic H2BK33Q and its deacetylase clr6 - 1 mutations compromise this fork stalling-induced chromatin compaction, cause physical separation of …
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Replication Fork Stalling at Natural Impediments
https://ase.tufts.edu/biology/labs/mirkin/documents/Mirkin_MMBR.pdf
Stalling of replication forks at natural impediments can either occur “on purpose” or be “accidental” (if inhibition of replication is a side effect of another biological process). Some-times, the distinction between the two scenarios is not obvious. The first instance includes termination of replication at bacte-
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