Keyword Analysis & Research: prontosil
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Prontosil - Wikipedia
https://en.wikipedia.org/wiki/Prontosil
WEBProntosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
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Prontosil | Sulfanilamide, Antibacterial, Antiseptic | Britannica
https://www.britannica.com/science/Prontosil
WEBProntosil, trade name of the first synthetic drug used in the treatment of general bacterial infections in humans. Prontosil was introduced into medicine in the 1930s. Prontosil resulted from research, directed by German chemist and pathologist Gerhard Domagk, on the antibacterial action of azo dyes. A red azo dye of low toxicity, Prontosil was ...
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Gerhard Domagk | Science History Institute
https://sciencehistory.org/education/scientific-biographies/gerhard-domagk/
WEBGerman pathologist Gerhard Domagk was forced to reject the Nobel Prize he won for his discovery of the first sulfa drug. Prontosil was the first drug to successfully treat bacterial infections and the first of many sulfa drugs—forerunners of antibiotics.
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Soldier Sulfa | Science History Institute
https://sciencehistory.org/stories/magazine/soldier-sulfa/
WEBApr 20, 2010 · Prontosil Rubrum was the first drug to cure bacterial infections and the first of many sulfa drugs. Tube of Prontosil tablets, ca. 1935–1950. In World War I, bacterial infections ravaged armies. Cholera left soldiers dead within days, and gas gangrene turned minor wounds into certain fatalities.
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Prontosil - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/prontosil
WEBProntosil, which was used initially as a dye material, showed antibacterial activity when administered to animals infected with hemolytic streptococci. It was soon discovered that the antibacterial activity was predominantly due to a metabolic product of Prontosil which was identified as sulfanilamide.
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Prontosil | C12H13N5O2S | CID 66895 - PubChem
https://pubchem.ncbi.nlm.nih.gov/compound/prontosil
WEBUSA.gov. Prontosil | C12H13N5O2S | CID 66895 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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The Discovery of Penicillin—New Insights After More Than 75 …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403050/
WEBDiscovery of Prontosil and Sulfa Drugs. This dismal outlook on chemotherapy began to change when Gerhard Domagk, a German pathologist and bacteriologist, found bacteriologic activity in a chemical derivative from oil dyes called sulfamidochrysoïdine (also known as Prontosil).
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Prontosil - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/chemistry/prontosil
WEBThe first important advance after the replacement of Prontosil by sulfanilamide came with the introduction of a heterocyclic group — pyridyl — on the sulfonamide nitrogen (N1 ). Sulphapyridine ( 106 ), introduced in 1938, was more potent than sulfanilamide and was effective against a wider range of bacteria.
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Prontosil - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/prontosil
WEBThe original sulphonamide, sulphanilamide, is the active principle of Prontosil, which holds a special place in medicine as the first agent to exhibit broad-spectrum activity against systemic bacterial disease (see Ch. 1). Within a few years of the introduction of Prontosil, numerous sulfonamide derivatives were synthesized.
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Prontosil - Chemical & Engineering News
https://cen.acs.org/articles/83/i25/Prontosil.html
WEBJun 20, 2005 · Prontosil was developed by Gerhard Domagk, working in the Bayer sector of I. G. Farbenindustrie. In 1927, Domagk was appointed director of Bayer's Institute of Pathology & Bacteriology, where he ...
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