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PCSK9 inhibitors: Pharmacology, adverse effects, and use
https://www.uptodate.com/contents/pcsk9-inhibitors-pharmacology-adverse-effects-and-use
WebJan 10, 2024 · Antibodies to PCSK9 have been approved by regulatory agencies for the treatment of individuals with inadequately treated levels of LDL-cholesterol (LDL-C). They are capable of lowering LDL-C by as much as 60 percent in patients on statin therapy.
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PCSK9 Inhibitors: How They Manage Cholesterol and Side Effects
https://my.clevelandclinic.org/health/drugs/22550-pcsk9-inhibitors
WebPCSK9 inhibitors are a type of medicine to lower cholesterol. They work by reducing your LDL cholesterol. Your provider might recommend a PCSK9 inhibitor if you have tried other treatments and your cholesterol is still high.
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PCSK9 Inhibitors: A Full List, Side Effects, and More - Healthline
https://www.healthline.com/health/pcsk9-inhibitors-what-you-need-to-know
WebSep 1, 2021 · PCSK9 inhibitors can help treat high cholesterol by directly modifying this gene to reduce the amount of LDL in your body. Learn about the PCSK9 gene, how PCSK9 inhibitors affect LDL...
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PCSK9 inhibition: A game changer in cholesterol management
https://www.mayoclinic.org/medical-professionals/cardiovascular-diseases/news/pcsk9-inhibition-a-game-changer-in-cholesterol-management/mac-20430713
WebPCSK9 inhibitors fill a therapeutic niche for patients with familial hypercholesterolemia or patients with statin intolerance who are not able to achieve the desired LDL-C level with conventional treatments.
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PCSK9 Inhibitors - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK448100/
WebMay 13, 2022 · PCSK9 inhibitors are recommended for the following groups: In patients with cardiovascular disease at very high risk whose LDL-C level remains ≥70 mg/dL (≥1.8 mmol/L) on a maximally tolerated statin and ezetimibe therapy, adding a …
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List of PCSK9 inhibitors - Drugs.com
https://www.drugs.com/drug-class/pcsk9-inhibitors.html
WebWhat are PCSK9 inhibitors? Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that binds to low-density lipoprotein receptors (LDL receptors), which stops LDL being removed from the blood, leading to an increase in blood levels of LDL. The PCSK9 inhibitor blocks the PCSK9 enzyme, resulting in more LDL receptors available to ...
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PCSK 9 Inhibitors: A Short History and a New Era of Lipid …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686613/
WebPCSK9 inhibitors are set to revolutionize the management of atherosclerotic risk. There are two FDA-approved medications: alirocumab (Praluent) and evolocumab (Repatha). Studies show that PCSK9 inhibitors have a powerful effect and in some cases can actually prevent heart attacks or strokes.
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PCSK9 inhibitors: Pharmacology, adverse effects, and use
https://www.uptodate.com/contents/pcsk9-inhibitors-pharmacology-adverse-effects-and-use/print
WebINTRODUCTION. Elevated levels of circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with increased low-density lipoprotein (LDL) and worse cardiovascular outcomes. Antibodies to PCSK9 have been approved by regulatory agencies for the treatment of individuals with inadequately treated levels of LDL-cholesterol (LDL-C).
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PCSK9 Inhibition: From Current Advances to Evolving Future
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562883/
WebSep 23, 2022 · PCSK9 inhibitors are mainly used in clinical hyperlipidemia, atherosclerosis (As), and related ischemic cardiovascular diseases with significant effects and can be used as a substitute for statins and ezetimibe [ 5, 6, 7, 8 ].
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How Do PCSK9 Inhibitors Lower Cholesterol? - WebMD
https://www.webmd.com/cholesterol-management/pcsk9-inhibitors-treatment
WebJun 4, 2022 · PCSK9 inhibitors are a new class of drugs that lower LDL, or “bad,” cholesterol. Right now, there are two FDA-approved medications: alirocumab ( Praluent) and evolocumab ( Repatha ). Studies...
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