Keyword Analysis & Research: n terminal degron
Keyword Research: People who searched n terminal degron also searched
Search Results related to n terminal degron on Search Engine
Functional dissection of the N-terminal degron of human ...
Previous studies have shown that proteolytic breakdown of the hTS polypeptide is directed by an intrinsically disordered 27-residue domain at the N-terminal end of the molecule. This domain, in co-operation with an α-helix spanning amino acids 31-45, functions as a degron…
DA: 62 PA: 49 MOZ Rank: 23
The N-end rule pathway and regulation by proteolysis
The main determinant of an N-degron is a destabilizing N-terminal residue of a protein. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system and consists of two branches, the Ac/N-end …
DA: 72 PA: 72 MOZ Rank: 81
N-degron and C-degron pathways of protein degradation …
Jan 08, 2019 · A proteolytic cleavage of a subunit in a multisubunit complex can create, at the same time, an N-degron (in a C-terminal fragment) and a spatially adjacent C-degron (in an N-terminal fragment). Consequently, both fragments of a subunit can be selectively destroyed through attacks by the N-degron and C-degron …
DA: 28 PA: 36 MOZ Rank: 51
The N-terminal domain of Rpn4 serves as a portable ...
Mar 09, 2012 · These two fragments were expressed in and purified from E. coliand subjected to in vitro degradation assays with purified 26S proteasome (Fig. 2A). Whereas the C-terminal fragment was stable, the N-terminal fragment was degraded, indicating that the Ub-independent degron is located in the N-terminal …
DA: 42 PA: 95 MOZ Rank: 88
Which is a determinant of an n-degron?
The main determinant of an N-degron is a destabilizing N-terminal residue of a protein. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system and consists of two branches, the Ac/N-end rule and the Arg/N-end rule pathways. The Ac/N-end rule pathway targets proteins containing N (α) -terminally acetylated (Nt-acetylated) residues.
DA: 35 PA: 97 MOZ Rank: 57
Where is C degron located in CLPs Leu / n recognin?
( C) The substrate-binding site of the E. coli ClpS Leu/N-recognin, which recognizes bulky hydrophobic Nt-residues ( 30, 52, 53 ). Modified with permission from ref. 35. The first example of physiologically relevant Ct-degradation signals, called C-degrons below, was identified in 1996.
DA: 96 PA: 33 MOZ Rank: 48
Which is not included in the N degron pathway?
Other studies, in the 1990s and afterward, have also identified many internal degrons, defined as degradation signals whose functionally essential elements do not include either Nt-residues or C-terminal (Ct) residues. Fig. 1. N-degron pathways.
DA: 88 PA: 26 MOZ Rank: 20
How is protein expression controlled with a degron?
Controlling protein expression using a degron is advantageous because the protein of interest can be rapidly depleted in a reversible manner. We pioneered the development of the auxin-inducible degron (AID) technology by transplanting a plant-specific degradation pathway to non-plant cells.
DA: 36 PA: 33 MOZ Rank: 75