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Lonidamine - Wikipedia
https://en.wikipedia.org/wiki/Lonidamine
WEBContents. hide. (Top) References. Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells.
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Lonidamine: Uses, Interactions, Mechanism of Action | DrugBank …
https://go.drugbank.com/drugs/DB06266
WEBMar 19, 2008 · Lonidamine (LND) is a drug that interferes with energy metabolism of cancer cells, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). In such way LND could impair energy-requiring processes, as recovery from potentially lethal damage, induced by radiation treatment and by some …
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Targeting lonidamine to mitochondria mitigates lung ... - Nature
https://www.nature.com/articles/s41467-019-10042-1
WEBMay 17, 2019 · Nature Communications - Brain metastases are a major reason for lung cancer mortality. Here, the authors modify lonidamine to target mitochondria, and show its therapeutic efficacy in...
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The Potential of Lonidamine in Combination with Chemotherapy …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696079/
WEBNov 11, 2020 · Lonidamine (LND), as a glycolytic inhibitor, although having low anticancer activity when used alone, exhibits selectivity to various tumors, and its adverse effects do not overlap when combined with other chemotherapeutic drugs. Therefore, LND may be very promising as a sensitizer of tumors to chemotherapeutic agents and physical …
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The anti-tumour agent lonidamine is a potent inhibitor of the
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814305/
WEBApr 1, 2016 · The mode of action of lonidamine, an established anti-tumour drug, remains controversial. We show that lonidamine potently inhibits the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters, accounting for many of its known effects on tumour cell metabolism and bioenergetics.
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Mechanism of Antineoplastic Activity of Lonidamine - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138080/
WEBAbstract. Lonidamine (LND) was initially introduced as an antispermatogenic agent. It was later found to have anticancer activity sensitizing tumors to chemo-, radio-, photodynamic-therapy and hyperthermia. Although the mechanism of action remained unclear, LND treatment has been known to target metabolic pathways in cancer cells.
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Lonidamine: efficacy and safety in clinical trials for the ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/12730701/
WEBLonidamine, a dechlorinate derivative of indazole-3-carboxylic acid, has proved to exert a powerful antiproliferative effect and to impair the energy metabolism of neoplastic cells. Herein we review the current experience on combining lonidamine and chemotherapy and/or radiation therapy in the treatment of solid tumors.
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Lonidamine - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/lonidamine
WEBLonidamine is a derivative of indazole-3-carboxilic acid and is known for its ability to inhibit aerobic glycolysis in cancer cells [92]. Under hypoxic conditions, as is common with cancers, lonidamine reduces ATP levels by interfering with membrane-bound HK2, as is also the case with 3-BrP.
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The anti-tumour agent lonidamine is a potent inhibitor of the
https://pubmed.ncbi.nlm.nih.gov/26831515/
WEBApr 1, 2016 · Lonidamine (LND) is an anti-tumour drug particularly effective at selectively sensitizing tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of action remains unclear. It has been reported to perturb the bioenergetics of cells by inhibiting glycolysis and mitochondrial respiration, whereas indirect evidence ...
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Lonidamine potentiates the oncolytic efficiency of M1 virus …
https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01598-w
WEBNov 2, 2020 · Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity | Cancer Cell International | Full Text. Primary research. Open access. Published: 02 November 2020.
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