Keyword Analysis & Research: insulin degludec to glargine conversion
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Interchange Recommendations - American Diabetes …
https://diabetes.org/sites/default/files/2019-08/switching-between-insulin.pdf
WEBToujeo® (glargine U-300) Tresiba® (degludec U-100 & U-200) Interchange Recommendations: Basal insulin analogs may be interchanged with NPH with a 20% reduction in dose and divided based on predicted meal frequency • if eating 2 meals per day- Split the new dose into ½ NPH with first meal of the day and ½ NPH with second …
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How to Switch Insulin Products - therapeuticresearch.com
https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2016/Dec/How-to-Switch-Insulin-Products-10473
WEBInsulin glargine U-100 (Lantus) to/from insulin glargine U-100 (Basaglar, Semglee, Rezvoglar [US]) Convert unit-per-unit. 5; Insulin detemir (Levemir) to insulin glargine U-100 (Lantus, Basaglar, Semglee, Rezvoglar [US]) Consider converting unit-per-unit. 5 A lower daily dose may be needed. 7; Give once daily. 5,18,30,35
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Practical guidance on the initiation, titration, and switching of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231382/
WEBJun 24, 2021 · A simple rule is to gradually increase the initial dose by 1 unit per day (NPH, insulin detemir, and glargine 100 units/mL) or 2–4 units once or twice per week (NPH, insulin detemir, glargine 100 and 300 units/mL, and degludec) until FPG levels remain consistently within the target range.
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Switching Between Glucagon-Like Peptide-1 Receptor Agonists: …
https://diabetesjournals.org/clinical/article/38/4/390/35426/Switching-Between-Glucagon-Like-Peptide-1-Receptor
WEBOct 1, 2020 · Lixisenatide is available as a fixed-ratio combination with insulin glargine 100 units/mL ; liraglutide 3.6 mg/mL plus insulin degludec 100 units/mL can also be given as a single injection . These combinations can be used in patients who need intensification of glucose-lowering therapies and are already on either a basal insulin or a GLP-1 ...
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Understanding the Clinical Profile of Insulin Degludec, the Latest
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547940/
WEBSep 17, 2020 · This study found statistically significant advantages for degludec over glargine U300 in terms of A1C reduction (estimated treatment difference − 0.3% [ p < 0.05]), a 30% lower risk of hypoglycemia (RR 0.70, p < 0.05), and a statistically significant 27% lower likelihood of treatment discontinuation.
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Concentrated Insulins: A Review and Recommendations - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375530/
WEBThe BEGIN Basal-Bolus trial series evaluated use of degludec combined with bolus insulin aspart in insulin-experienced patients with T2DM (n = 992) and type 1 DM (T1DM) (n = 629) over 52 weeks.10,11 Both trials found noninferiority in A 1c reduction: 1.1% (degludec) and 1.18% (glargine) in patients with T2DM and 0.4% (degludec) and 0.39% ...
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Type 2 Diabetes Mellitus: Outpatient Insulin Management | AAFP
https://www.aafp.org/pubs/afp/issues/2018/0101/p29.html
WEBJan 1, 2018 · Low-volume insulin degludec 200 units/ml once daily improves glycemic control similarly to insulin glargine with a low risk of hypoglycemia in insulin-naive patients with type 2...
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1025-P: Degludec-to-Glargine Transition: The First Real-World …
https://diabetesjournals.org/diabetes/article/69/Supplement_1/1025-P/60846/1025-P-Degludec-to-Glargine-Transition-The-First
WEBJun 1, 2020 · Get Permissions. Switching from insulin degludec (iDeg) to another basal insulin is often needed upon admission. No study has reported glycemic data or how clinicians switch patients from iDeg to insulin glargine …
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Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
https://www.nejm.org/doi/full/10.1056/NEJMoa1615692
WEBAug 24, 2017 · Methods. We randomly assigned 7637 patients with type 2 diabetes to receive either insulin degludec (3818 patients) or insulin glargine U100 (3819 patients) once daily between dinner and...
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INFORMATION FOR HEALTH CARE PROFESSIONALS …
https://diabetes.org/sites/default/files/2022-03/Switching-Between-Insulin-Products-in-Humanitarian-Response-2022-Easter-Europe-3-18-2022-DDRC-English-v3.pdf
WEBMar 18, 2022 · insulin (see above) with a 10-20% reduction in the dose and splitting the dose into two equal doses given approximately 12 hours apart. Examples of combined LONG-acting insulins AND GLP-1 agonist: Soliqua® (insulin glargine/lixisenatide) Xultophy® or Klastofai® (insulin degludec/liraglutide) UNIQUE INSULIN THERAPIES
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