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GZMB - Wikipedia
https://en.wikipedia.org/wiki/GZMB
GZMB - Wikipedia. Granzyme B is a serine protease that in humans is encoded by the GZMB gene. [3] . Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells.
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GZMB Gene - GeneCards | GRAB Protein | GRAB Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GZMB
Jan 3, 2024 · GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Peripheral T-Cell Lymphoma and Severe Cutaneous Adverse Reaction. Among its related pathways are Programmed Cell Death and RIPK1-mediated regulated necrosis.
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Granzyme B - Wikipedia
https://en.wikipedia.org/wiki/Granzyme_B
In humans, granzyme B is encoded by GZMB on chromosome 14q.11.2, which is 3.2kb long and consists of 5 exons. It is one of the most abundant granzymes of which there are 5 in humans and 10 in mice. Granzyme B is thought to have evolved from a granzyme H related precursor and is more effective at lower concentrations than the other granzymes.
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GZMB granzyme B [Homo sapiens (human)] - Gene - NCBI
https://www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=3002
Mar 10, 2024 · This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by …
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Granzyme B inhibition reduces disease severity in autoimmune
https://www.nature.com/articles/s41467-020-20604-3
Jan 12, 2021 · GzmB mediates loss of hemidesmosomal proteins, type XVII collagen (COL17) and α6 integrin, in an EBA murine model. We next aimed to elucidate the mechanisms underlying GzmB-mediated PD...
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A fluorogenic probe for granzyme B enables in-biopsy ... - Nature
https://www.nature.com/articles/s41467-022-29691-w
May 2, 2022 · The chemical design of activity-sensing reporters of granzyme B (GzmB) represents a potentially effective strategy for monitoring the cytotoxic activity of CD8+ T cells in cancer.
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Emerging Canonical and Non-Canonical Roles of Granzyme B in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946077/
Mar 10, 2022 · Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its discovery, there has been growing evidence showing more roles besides cell death such as tissue development and repair.
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Granzyme B in skin inflammation and disease - PubMed
https://pubmed.ncbi.nlm.nih.gov/29247692/
152477/CIHR/Canada. Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ulcers, hypertrophic scarring, autoimmune skin d ….
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Granzyme B degrades extracellular matrix and contributes to
https://www.nature.com/articles/cdd201396
Aug 2, 2013 · Granzyme B (GzmB) is a serine protease expressed during chronic inflammation that, in conjunction with perforin, has a well-established role in initiating apoptotic cell death. GzmB is also...
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3002 - Gene ResultGZMB granzyme B [ (human)] - National Center …
https://www.ncbi.nlm.nih.gov/gene/3002
Granzyme B: A novel therapeutic target for treatment of atopic dermatitis. Granzyme B in Autoimmune Skin Disease. Granzyme B as a therapeutic target: an update in 2022. Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders.
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