Keyword Analysis & Research: gain of function
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What is 'gain-of-function' and why does it matter in the search for
https://phys.org/news/2021-06-gain-of-function-sars-cov-.html
WEBJun 21, 2021 · What does gain of function mean? Any organism can acquire a new ability or property, or "gain" a "function." This can happen through natural selection or a researcher's...
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Gain-of-function research - Wikipedia
https://en.wikipedia.org/wiki/Gain-of-function_research
WEBGain-of-function research ( GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e., the types of hosts that a microorganism can infect.
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Gain-of-function research is more than just tweaking risky viruses …
https://theconversation.com/gain-of-function-research-is-more-than-just-tweaking-risky-viruses-its-a-routine-and-essential-tool-in-all-biology-research-202084
WEBMay 8, 2023 · What is gain of function? To study how a living thing operates, scientists can change a specific part of it and then observe the effects. These changes sometimes result in the organism’s gaining...
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What is Gain-of-Function Research? - News-Medical.net
https://www.news-medical.net/health/What-is-Gain-of-Function-Research.aspx
WEBSep 4, 2022 · Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host …
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Loss-of-function, gain-of-function and dominant-negative ... - Nature
https://www.nature.com/articles/s41467-022-31686-6
WEBPublished: 06 July 2022. Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure. Lukas Gerasimavicius, Benjamin J....
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Gain-of-Function Research: Background and Alternatives
https://www.ncbi.nlm.nih.gov/books/NBK285579/
WEBApr 13, 2015 · TYPES OF GAIN-OF-FUNCTION (GOF) RESEARCH. Subbarao explained that routine virological methods involve experiments that aim to produce a gain of a desired function, such as higher yields for vaccine strains, but often also lead to loss of function, such as loss of the ability for a virus to replicate well, as a consequence.
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What is “gain-of-function” research? - The Economist
https://www.economist.com/the-economist-explains/2021/11/01/what-is-gain-of-function-research
WEBNov 1st 2021. DISQUIET IS growing about “gain-of-function” (GOF) research, a form of genetic manipulation on micro-organisms. Some anxiety stems from the idea that such work was responsible...
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Introduction - Gain-of-Function Research - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK373321/
WEBJun 20, 2016 · Gain-of-Function Research: Summary of the Second Symposium, March 10-11, 2016. Show details. Contents. Hardcopy Version at National Academies Press. < Prev Next > 1 Introduction.
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First global survey reveals who is doing ‘gain of function’ research …
https://www.nature.com/articles/d41586-023-02873-2
WEB15 September 2023. First global survey reveals who is doing ‘gain of function’ research on pathogens and why. An analysis of the controversial work indicates that a one-size-fits-all...
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The shifting sands of ‘gain-of-function’ research - Nature
https://www.nature.com/articles/d41586-021-02903-x
WEB27 October 2021. The shifting sands of ‘gain-of-function’ research. The mystery of COVID’s origins has reignited a contentious debate about potentially risky studies and the fuzzy terminology...
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