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ESR1 Gene - GeneCards | ESR1 Protein | ESR1 Antibody
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ESR1
WebApr 3, 2024 · ESR1 (Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with ESR1 include Estrogen Resistance and Breast Cancer. Among its related pathways are PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling and ESR-mediated signaling.
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ESR1 Mutations in Breast Cancer - PMC - National Center for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788940/
WebNov 1, 2019 · Abstract. The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor (AI) therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common mechanism of hormonal therapy resistance. Preclinical and clinical studies have demonstrated that ESR1 mutations can pre-exist in primary tumors and can be …
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ESR1 mutant breast cancers show elevated basal cytokeratins
https://www.nature.com/articles/s41467-022-29498-9
WebApr 19, 2022 · Estrogen receptor alpha (ER/ ESR1) is frequently mutated in endocrine resistant ER-positive (ER+) breast cancer and linked to ligand-independent growth and metastasis. Despite the distinct...
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MSK Discovery of ESR1 Gene Mutation Leads to Approval of …
https://www.mskcc.org/news/msk-discovery-of-esr1-gene-mutation-leads-to-approval-of-breast-cancer-drug-elacestrant
WebMay 3, 2023 · We discovered that ESR1 gene mutations convert the estrogen receptor into a shape that mimics the form the receptor takes when binding to estrogen. That means that even in the absence of the estrogen signal, the receptor’s “on” …
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ESR1 mutations and therapeutic resistance in metastatic breast …
https://www.nature.com/articles/s41416-021-01564-x
WebOct 7, 2021 · One major driver of ET resistance is mutations in the ER gene ( ESR1) leading to constitutive transcriptional activity and reduced ET sensitivity. These mutations are particularly detrimental in...
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ESR1 estrogen receptor 1 [Homo sapiens (human)] - Gene - NCBI
https://www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=2099
WebApr 11, 2024 · Summary. This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain.
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ESR1 - My Cancer Genome
https://www.mycancergenome.org/content/gene/esr1/
WebESR1 (estrogen receptor 1, also known as ER) is a gene that encodes the estrogen receptor protein. ESR1 plays a role in pathogenesis of cancers such as breast, endometrial, and prostate cancer (PMID: 21779010).
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Genome engineering for estrogen receptor mutations reveals
https://www.nature.com/articles/s41388-022-02483-8
WebOct 5, 2022 · Mutations in the estrogen receptor (ESR1) gene are common in ER-positive breast cancer patients who progress on endocrine therapies. Most mutations localise to just three residues at, or near,...
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2099 - Gene ResultESR1 estrogen receptor 1 [ (human)]
https://www.ncbi.nlm.nih.gov/gene/2099/
WebApr 3, 2024 · TMPO-AS1 could positively regulate estrogen receptor 1 (ESR1) mRNA expression by stabilizing ESR1 mRNA through interaction with ESR1 mRNA. ERBB2 mutations hyperactivate the HER3/PI3K/AKT/mTOR axis, leading to antiestrogen resistance in ER+ breast cancer.
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ESR1 activating mutations: From structure to clinical application
https://www.sciencedirect.com/science/article/pii/S0304419X2200155X
WebJan 1, 2023 · ESR1, the gene spanning q24-q27 of chromosome 6 that encodes for estrogen receptor alpha (ER), is the nuclear transcription factor most commonly implicated in breast cancer [2]. Approximately 70–75% of breast cancers express ER, making the ER-positive (ER+) subtype the most prevalent molecular subtype of both early and advanced …
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