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Salicylic Acid (Aspirin) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK519032/
WEBJul 5, 2023 · Mechanism of Action. Aspirin is a cyclooxygenase-1 (COX-1) inhibitor. It is a modifier of the enzymatic activity of cyclooxygenase-2 (COX-2). Unlike other NSAIDs (ibuprofen/naproxen), which bind reversibly to this enzyme, aspirin binding is irreversible. It also blocks thromboxane A2 on platelets in an irreversible fashion preventing platelet ...
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Mechanism of action of aspirin - Wikipedia
https://en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin
WEBMechanism of action of aspirin. Tridimensional model of the chemical structure of aspirin. Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever.
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Aspirin: Uses, Interactions, Mechanism of Action | DrugBank Online
https://go.drugbank.com/drugs/DB00945
WEBMechanism of action. Acetylsalicylic acid (ASA) blocks prostaglandin synthesis. It is non-selective for COX-1 and COX-2 enzymes 9,10,11. Inhibition of COX-1 results in the inhibition of platelet aggregation for about 7-10 days (average platelet lifespan).
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New insights into the mechanisms of action of aspirin and its use …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590672/
WEBSep 24, 2015 · Mechanisms of action of aspirin. Acetylsalicylic acid acts as an acetylating agent. Thus, aspirin irreversibly inactivates cyclooxygenase (COX)-1 and suppresses the generation of prostaglandin H 2 (a precursor of thromboxane A 2).
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Aspirin: Pharmacology and Clinical Applications - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236360/
WEBNov 17, 2011 · Aspirin belongs to the group of drugs that inhibit platelet activation. As seen before, platelet activation can be blocked by inhibited the TXA 2 pathway, ADP pathway, thrombin pathway, and phosphodiesterase (PDE). Aspirin meets its effects by inhibiting the TXA 2 pathway in a dose-dependent manner.
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NSAIDs (including aspirin): Pharmacology and mechanism of action
https://www.uptodate.com/contents/nsaids-including-aspirin-pharmacology-and-mechanism-of-action
WEBFeb 5, 2024 · The pharmacology and mechanisms of action of the NSAIDs, including aspirin, will be reviewed here. A more detailed discussion of mechanism of aspirin relevant to primary prevention of cardiovascular disease and cancer can be found elsewhere. (See "Aspirin in the primary prevention of cardiovascular disease and cancer", section on …
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The mechanism of action of aspirin - PubMed
https://pubmed.ncbi.nlm.nih.gov/14592543/
WEBJun 15, 2003 · In 1971, Vane discovered the mechanism by which aspirin exerts its anti-inflammatory, analgesic and antipyretic actions. He proved that aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause …
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Aspirin | Circulation - AHA/ASA Journals
https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.111.046243
WEBMar 13, 2012 · Noncoated aspirin acts within minutes of ingestion to stop platelets from forming blood clots. Enteric-coated aspirin takes longer to work but acts just as quickly as uncoated aspirin if chewed. Aspirin reduces the severity of heart attacks and strokes and prevents future heart attacks and strokes.
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Frontiers | Aspirin: The Mechanism of Action Revisited in the …
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00261/full
WEBThe most recognized mechanism of action of aspirin is to inhibit the synthesis of prostaglandins but this by itself does not explain the repertoire of anti-inflammatory effects of aspirin.
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Mechanistic Insights into a Classic Wonder Drug—Aspirin
https://pubs.acs.org/doi/10.1021/ja5112964
WEBDec 16, 2014 · The principal pharmacological effects of aspirin are known to arise from its covalent modification of cyclooxygenase-2 (COX-2) through acetylation of Ser530, but the detailed mechanism of its biochemical action and specificity remains to be elucidated.
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