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Cubicin (daptomycin) - antimicrobe.org
http://www.antimicrobe.org/pharma/daptomycin.asp
WEBDaptomycin is the first of a new class of antibiotics, the cyclic lipopeptides. It exerts bactericidal action via depolarization of the cell membrane in a rapid (1 hour) and concentration-dependent manner with a post-antibiotic effect. It possesses broad activity against Gram-positive pathogens, such as Streptococcus, Staphylococcus (including ...
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Daptomycin - Antimicrobe
http://www.antimicrobe.org/new/drugpopup/Daptomycin.pdf
WEBDaptomycin . Antibiotic Class: . Lipopeptide. Antimicrobial Spectrum: Gram-positive bacteria. Mechanism of Action: Calcium-dependent binding/insertion of the lipophillic tail into gram-positive cyotplasmic membrane. Oligomerization/channel formation occurs with subsequent ion leakage and collapse of organism leading to cell death. (Figure 2) .
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Daptomycin: An overview - UpToDate
https://www.uptodate.com/contents/daptomycin-an-overview
WEBMar 7, 2023 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ]. Issues related to pharmacokinetic and pharmacodynamic considerations, challenges with susceptibility …
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Daptomycin - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK470407/
WEBDec 11, 2022 · Daptomycin is a cyclic lipopeptide antibiotic derived from the organism Streptomyces roseosporus. Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
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Daptomycin - Infectious Diseases - Merck Manuals Professional Edition
https://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-drugs/daptomycin
WEBDaptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis; the result is rapid concentration-dependent bacterial death. Indications for Daptomycin.
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Daptomycin - Wikipedia
https://en.wikipedia.org/wiki/Daptomycin
WEBDaptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. [3] Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019.
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Efficacy and safety of daptomycin: systematic review and meta …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005973/
WEBNov 7, 2019 · Daptomycin is a lipopeptide antibiotic with a broad spectrum of activity against clinically relevant gram-positive bacteria, including S. aureus regardless of methicillin susceptibility. In addition, it demonstrates significant activity against VRE.
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Daptomycin - Infections - MSD Manual Consumer Version
https://www.msdmanuals.com/home/infections/antibiotics/daptomycin
WEBThe antibiotic daptomycin is used to treat many serious bacterial infections, such as those caused by gram-positive bacteria , including those that are resistant to many other antibiotics. Daptomycin works by interfering with the bacteria's cell membrane, which results in rapid death of the bacteria. Table. Daptomycin.
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Daptomycin: A novel cyclic lipopeptide antimicrobial
https://academic.oup.com/ajhp/article/62/11/1145/5135874
WEBJun 1, 2005 · Daptomycin, a novel cyclic lipopeptide antimicrobial, is bactericidal against a range of gram-positive bacteria, including many multiple-drug-resistant isolates. It has only minimal activity against anaerobic bacteria and no activity against gram-negative bacteria.
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Daptomycin: a lipopeptide antibiotic for the treatment of serious …
https://academic.oup.com/jac/article/55/3/283/758329
WEBMar 1, 2005 · Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI).
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