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Rumack–Matthew nomogram - Wikipedia
https://en.wikipedia.org/wiki/Rumack–Matthew_nomogram
WEBThe Rumack–Matthew nomogram, also known as the acetaminophen nomogram, is an acetaminophen toxicity nomogram. It plots serum concentration of acetaminophen against the time since ingestion, in order to predict possible liver toxicity and allow a clinician to decide whether to proceed with N-Acetylcysteine (NAC) treatment.
DA: 70 PA: 27 MOZ Rank: 80
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ACETAMINOPHEN NOMOGRAM - Missouri Poison Center
https://missouripoisoncenter.org/wp-content/uploads/2021/12/ACETAMINOPHEN-NOMOGRAM.pdf
WEBACETAMINOPHEN NOMOGRAM. CAUTION: The nomogram is valid only after a single acute overdose with serum APAP levels drawn 4 hours up to 24 hours after the overdose. Levels drawn too early or too late cannot be interpreted by the nomogram, and the need for treatment must be made by clinical judgement.
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Figure: Rumack-Matthew nomogram for single acute acetaminophen
https://www.merckmanuals.com/professional/multimedia/figure/rumack-matthew-nomogram-for-single-acute-acetaminophen-ingestions
WEBRumack-Matthew nomogram for single acute acetaminophen ingestions. Semilogarithmic plot of plasma acetaminophen levels vs time. Cautions for use of this nomogram: The time coordinates refer to time after ingestion. Serum levels drawn before 4 hours may not represent peak levels.
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Management of Acetaminophen Poisoning in the US and Canada …
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2808062
WEBAug 8, 2023 · An acetaminophen concentration sample drawn before 4 hours after ingestion cannot be used to risk-stratify patients on the acetaminophen nomogram. A nondetectable concentration at 2 to 4 h after ingestion typically excludes significant ingestion, but consultation with a poison center or toxicologist is recommended.
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Guidelines for the Management of Acetaminophen Overdose
https://www.tylenolprofessional.com/sites/tylenol_hcp_us/files/acetaminphen_overdose_treatment_info.pdf
WEBIncluded herein are flowcharts for managing both acute and chronic acetaminophen overdose, and a nomogram, which uses acetaminophen serum concentrations at various time intervals following a single, acute overdose to determine whether the antidote should be administered.
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Acetaminophen (paracetamol) poisoning in adults ... - UpToDate
https://www.uptodate.com/contents/acetaminophen-paracetamol-poisoning-in-adults-pathophysiology-presentation-and-evaluation
WEBDec 5, 2023 · Not surprisingly, acetaminophen remains a major cause of overdose and overdose-related liver failure and death in the United States and many other countries . If overdose is identified early enough, mortality rates are extremely low.
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Acetaminophen (paracetamol) poisoning: Management in adults ... - UpToDate
https://www.uptodate.com/contents/acetaminophen-paracetamol-poisoning-management-in-adults-and-children
WEBDec 5, 2023 · Evaluation and diagnosis of acetaminophen poisoning, use of the Revised Rumack-Matthew nomogram, and determination of risk of liver injury (see "Acetaminophen (paracetamol) poisoning in adults: Pathophysiology, presentation, and evaluation" and "Clinical manifestations and diagnosis of acetaminophen (paracetamol) …
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Clinical manifestations and diagnosis of acetaminophen ... - UpToDate
https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-acetaminophen-paracetamol-poisoning-in-children-and-adolescents
WEBDec 5, 2023 · Literature review current through: Jan 2024. This topic last updated: Dec 05, 2023. INTRODUCTION. Since its clinical introduction in 1950, acetaminophen (N-acetyl-p-aminophenol; APAP; paracetamol) has become the most widely used analgesic and antipyretic in the United States.
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Acetaminophen Treatment Nomogram | New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJM199406303302619
WEBJun 30, 1994 · The acetaminophen treatment nomogram is widely used as a guideline for acetylcysteine therapy in patients with an acetaminophen overdose 1. However, the potential toxicity of acetaminophen...
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Sensitivity of dose‐estimations for acute acetaminophen …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929339/
WEBFeb 1, 2022 · In a retrospective study, sensitivity and specificity of ingested acetaminophen dose 150 mg/kg to predict the 150 mg/L treatment line in the Rumack Matthew Nomogram in acute acetaminophen overdose were 92.6% and 55.3%, respectively. Among patients whose dose estimates were below 150 mg/kg, 7.1% developed acute liver injury.
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