Keyword Analysis & Research: sideroflexin
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Sideroflexin 4 is a complex I assembly factor that interacts ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.2115566119
Web ResultSideroflexins (SFXNs) are a family of inner membrane proteins that are evolutionarily distinct from the SLC25A mitochondrial carrier family, although both protein …
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Insights into the Roles of the Sideroflexins/SLC56 Family in Iron
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911444/
Web ResultJan 21, 2021 · Sideroflexins (SLC56 family) are highly conserved multi-spanning transmembrane proteins inserted in the inner mitochondrial membrane in eukaryotes. Few data are available on their molecular function, but since their first description, they were thought to be metabolite transporters probably required for iron …
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SFXN1 is a mitochondrial serine transporter required for one ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/30442778/
Web ResultNov 16, 2018 · In a CRISPR-based genetic screen in human cells for genes of the mitochondrial pathway, we found sideroflexin 1 (SFXN1), a multipass inner mitochondrial membrane protein of unclear function. Like cells missing mitochondrial components of one-carbon metabolism, those null for SFXN1 are defective in …
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Insights into the Roles of the Sideroflexins/SLC56 Family in Iron
https://pubmed.ncbi.nlm.nih.gov/33494450/
Web ResultJan 21, 2021 · Sideroflexins (SLC56 family) are highly conserved multi-spanning transmembrane proteins inserted in the inner mitochondrial membrane in eukaryotes. Few data are available on their molecular function, but since their first description, they were thought to be metabolite transporters probably required ….
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Exploring the novel duo of Reticulocalbin, and Sideroflexin as …
https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-024-09459-8
Web ResultFeb 14, 2024 · Our study discovered a novel duo of proteins reticulocalbin-1, and sideroflexin-4 that showed potential as valuable future biomarkers for the diagnosis and clinical management of COPD exacerbations. COPD is a complex respiratory disorder with high morbidity and mortality rates.
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Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons
https://pubmed.ncbi.nlm.nih.gov/31177362/
Web ResultSideroflexin 1 (Sfxn1) is a mitochondrial serine transporter involved in one-carbon metabolism in blood and cancer cell lines. The expression of other Sfxn homologs varies across tissues implying that each homolog may have tissue-specific functions. RNA databases suggest that among the Sfxns, Sfxn3 …
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Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism
https://www.nature.com/articles/s41598-019-55907-z
Web ResultDec 23, 2019 · 25 Citations. Metrics. Abstract. Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of...
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Complementary anti-cancer pathways triggered by inhibition of
https://www.nature.com/articles/s41598-022-24391-3
Web ResultNov 19, 2022 · Sideroflexin 4 (SFXN4) is a little-studied inner mitochondrial membrane protein. Here we demonstrate that SFXN4 plays a role in synthesis of iron sulfur clusters (Fe-S) in ovarian cancer cells...
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Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons
https://link.springer.com/article/10.1007/s12017-019-08553-7
Web ResultJun 8, 2019 · Amorim, I. S., Graham, L. C., Carter, R. N., Morton, N. M., Hammachi, F., Kunath, T., et al. (2017). Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Journal of Cell Science, 130, 325–331. Article CAS PubMed PubMed Central Google Scholar
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Prospective role and immunotherapeutic targets of sideroflexin …
https://link.springer.com/article/10.1007/s10142-022-00883-3
Web ResultJul 19, 2022 · Home. Functional & Integrative Genomics. Article. Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation. Original Article. Published: 19 July 2022. Volume 22 , pages 1057–1072, ( 2022 ) Cite this article. Download PDF. Huy …
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